Biography:

Dr. Ken Mackie is a Distinguished Professor of Psychological and Brain Sciences at Indiana University Bloomington and an Adjunct Professor of Anesthesiology at Indiana University School of Medicine.  He is also a Linda and Jack Gill Chair and the former Director of the Gill Center for Biomolecular Science at Indiana University Bloomington.  He received his M.D. from Yale University, and completed an internship and residency at Yale University and the University of Washington, respectively.  He did post-doctoral work at Rockefeller University and the University of Washington.  For fifteen years he combined an active laboratory-based program in cannabinoid research with clinical care in anesthesiology at the University of Washington.  In 2007 he was recruited to Indiana University Bloomington as a Gill Chair in neuroscience.  Dr. Mackie’s research interests focus on understanding the relationships between phytocannabinoids (such as THC and CBD), terpenes, endocannabinoids, and the pharmacological and physiological responses to both.  His special interests include the potential detrimental effects of cannabis on the developing brain as well as potential therapeutic benefits of modulating the endocannabinoid system.  His lab takes diverse approaches (imaging, electrophysiological, behavioral, molecular, and biochemical) to address these questions. 

Representative Publications

  1. Howlett, A. C., F. Barth, T. I. Bonner, G. Cabral, P. Casellas, W. A. Devane, C. C. Felder, M. Herkenham, K. Mackie, B. R. Martin, R. Mechoulam and R. G. Pertwee (2002). International union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacological Reviews 54(2): 161-202.
  2. Mackie, K. (2006). Cannabinoid receptors as therapeutic targets. Annual Review of Pharmacology and Toxicology. Palo Alto, Annual Reviews. 46: 101-122.
  3. Lu, H.C. and K. Mackie (2016). An introduction to the endogenous cannabinoid system. Biol. Psychiatry 79(7): 516-525. PMCID: PMC4789136.
  4. Atwood, B. K. and K. Mackie (2010). CB(2): A cannabinoid receptor with an identity crisis. British Journal of Pharmacology 160(3): 467-479. PMCID: PMC2931549.

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