Biography

Dr. Hui-Chen Lu, Ph.D. is a Professor of Psychological and Brain Sciences at Indiana University, Bloomington, IN (IUB). She is also a Linda and Jack Gill Chair of Neuroscience and the current Director of the Gill Center for Biomolecular Science at IUB. Dr. Lu was one of three initial students to enroll in the Baylor College of Medicine in Houston's first developmental biology Ph.D. program. She diversified her training through a postdoctoral under neuroscientist Michael Crair, where she became increasingly interested in brain development. She took on an assistant professorship in the same department. She was recruited to join the Linda and Jack Gill Center in 2015, and became the director of the Center in 2018, superceding Dr. Mackie.

Dr. Lu's research focuses on the signaling cascades underlying neural circuit connections during brain development, to understand how sensory experiences affect neural circuit wiring, and to identify novel factors required to maintain the health of neural circuits during aging.

Representative Publications

  1. Sen Yang, Jung Hyun Park, Hui-Chen Lu (2023). Axonal energy metabolism, and the effects in aging and neurodegenerative diseases. Mol Neurodegeneration.18(1):49. doi: 10.1186/s13024-023-00634-3.
  2. Chiaki Itami, Naofumi Uesaka, Jui-Yen Huang, Hui-Chen Lu, Kenji Sakimura, Masanobu Kano, Fumitaka Kimura (2022) “Endocannabinoid-dependent formation of columnar axonal projection in the mouse cerebral cortex. Proc Natl Acad Sci U S A Sep 13;119(37):e2122700119.
  3. Izaque S. Maciel, Gabriel HD de Abreu, Claire T. Johnson, Rida Bonday, Heather B. Bradshaw, Ken Mackie, Hui-Chen Lu (2021) “Perinatal CBD or THC Exposure Results in Lasting Resistance to Fluoxetine in the Forced Swim Test: Reversal by Fatty Acid Amide Hydrolase Inhibition. Cannabis Cannabinoid Res.
  4. Gregory G. Grecco, Briana Mork, Jui Yen Huang, Corinne E. Metzger, David L. Haggerty, Kaitlin C. Reeves, Yong Gao, Hunter Hoffman, Simon N. Katner, Andrea R. Masters, Cameron W. Morris, Erin A. Newell, Eric A. Engleman, Anthony J. Baucum II, Jieun Kim, Bryan K. Yamamoto, Matthew R. Allen, Yu-Chien Wu, Hui-Chen Lu, Patrick L. Sheets, Brady K. Atwood (2021) “Prenatal methadone exposure disrupts behavioral development and alters motor neuron intrinsic properties and local circuitry”, Elife. doi: 10.7554/eLife.66230.
  5. Hui-Chen Lu, Ken Mackie (2020) Review of the Endocannabinoid System. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2020;:S2451902220302068.

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